Presentations

The following presentations have been given on the results of the BALI project:

K. Lohner 245th Amer. Chem. Soc. National Meeting, New Orleans, USA, April 2013 (Invited Talk) Nature of target lipid influences interfacial activity of amphipathic peptides.

N. Malanovic, M. Schmuck, M. Kriechbaum, J.W. Drijfhout and K. Lohner. FEBS/EMBO Advanced Lecture Courses, Cargese, Corsica, France, June 2013 (Poster) Lipid-specific mode of interaction of OP-145, a synthetic membrane-active peptide derived from the human cathelicidin LL-37.

T.F. Moriarty et al. Asia Pacific Orthopaedic Association annual meeting, Kuching, Malaysia, August 2013 (Talk) Antimicrobial peptides and controlled release polymers for infection prophylaxis.

N. Malanovic, M. Schmuck, M. Kriechbaum, J.W. Drijfhout and K. Lohner. IMAP 2013, London, UK, September 2013 (Invited Talk) OP-145, a synthetic membrane-active peptide derived from the human cathelicidin LL-37, as a potential therapeutic agent in orthopaedics

N. Malanovic, J.W. Drijfhout, A. de Breij, P.H. Nibbering and K. Lohner IMAP 2013, London, UK, September 2013 (Poster) Modifying the hydrophobic face of the amphipathic alpha-helical peptide, OP-145, affects membrane specificity and activity.

S.A.J. Zaat Biomaterial Research Center’s Annual Day, Gothenburg, Sweden, November 2013 (Invited Talk) Biomaterial-associated infection: surfaces, tissue and zebrafish.

N. Malanovic, J.W. Drijfhout, M. Kriechbaum, M. Schmuck, A. de Breij, P.H. Nibbering and K. Lohner BSM, San Francisco, USA, February 2014 (Talk) Point mutation in the hydrophobic region drives selectivity and activity of OP-145, a derivative of human cathelicidin LL-37.(Published: Biophys. J., 106 (2, Suppl 1) 2014, 442a)

P.H.S. Kwakman, M. Riool, L. de Boer, A. de Breij, P.H. Nibbering, J.W. Drijfhout and S.A.J. Zaat Dutch society of (medical) microbiology (KNVM/NVMM), Arnhem, The Netherlands, April 2014 (Poster) Development of novel Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) using the trombocidin-1 derived peptide L3 as a scaffold. (Published: Ned. Tijdschr. Med. Microbiol., 22 (Suppl) 2014)

P.H.S. Kwakman, M. Riool, L. de Boer, A. de Breij, P.H. Nibbering, J.W. Drijfhout and S.A.J. Zaat ALTANT, Utrecht, The Netherlands, May 2014 (Poster) Development of novel Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) using the trombocidin-1 derived peptide L3 as a scaffold.

A. de Breij, T. van der Heijde, R.A. Cordfunke, P.S. Hiemstra, J.W. Drijfhout and P.H. Nibbering ALTANT, Utrecht, The Netherlands, May 2014 (Talk) Next generation antimicrobial peptides based on OP-145, a derivative of the human cathelicidin LL-37, with improved antimicrobial and antibiofilm activities in plasma.

S.A.J. Zaat International Conference on Tissue Engineering, Kos, Greece, June 2014 (Invited Talk) Prevention of infection and immune-dysregulation around biomaterials utilizing novel synthetic antimicrobial antibiofilm peptides from BALI.

N. Emanuel, O. Cohen, Y. Rosenfeld, R.G. Richards and T.F. Moriarty European Orthopedic Research Society (EORS), Nantes, France, July 2014 (Talk) E¬fficacy of a lipid-and-polymer-based PolyPid drug delivery coating containing doxycycline to prevent implant-related infection.

S.A.J. Zaat Thesinge biofilm meeting, Thesinge, The Netherlands, September 2014 (Talk) Synthetic antimicrobial antibiofilm peptides from controlled release coatings to prevent implant-associated infection and derangement of immune responses.

M. Riool, P.H.S. Kwakman, L. de Boer, A. de Breij, P.H. Nibbering, L.T. Nguyen, H.J. Vogel, J.W. Drijfhout and S.A.J. Zaat Thesinge biofilm meeting, Thesinge, The Netherlands, September 2014 (Poster) Development of novel Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) using the trombocidin-1 derived peptide L3 as a scaffold.

S.A.J. Zaat International Meeting on Antimicrobial Peptides (IMAP), Graz, Austria, September 2014 (Invited Talk) BALI Beating Biofilms.

N. Malanovic, R. Leber, M. Kriechbaum ,J.W. Drijfhout and K. Lohner IMAP 2014, Graz, Austria, September 2014 (Talk) Interaction of OP-145, a derivative of human cathelicidine LL-37, with bacterial plasma membrane and cell wall components: impact of secondary structure and aggregation status.

N. Malanovic, R. Leber, M. Kriechbaum ,J.W. Drijfhout and K. Lohner ICAR 2014, Madrid, Spain, October 2014 (Talk) Interaction of OP-145, a derivative of human cathelicidine LL-37, with bacterial plasma membrane and cell wall components: impact of secondary structure and aggregation status.

S.A.J. Zaat, M. Riool, A. de Breij, P.H.S. Kwakman, L. de Boer, P.H. Nibbering, R.A. Cordfunke, J.W. Drijfhout, P.S. Hiemstra, N. Malanovic, K. Lohner, O. Cohen, N. Emanuel, M. Reichert, T.F. Moriarty, T. Schmidt, M.P. de Baar, R. van Leeuwen and A. Faeh Gordon Research Conference on Antimicrobial peptides, Italy, April 2015 (Poster) Prevention of infection and immune dysregulation around biomaterials utilizing novel synthetic antimicrobial antibiofilm peptides from BALI.

M. Riool, L. de Boer, P.H.S. Kwakman, A. de Breij, P.H. Nibbering, J.W. Drijfhout and S.A.J. Zaat Dutch society of (medical) microbiology (KNVM/NVMM), Arnhem, The Netherlands, April 2015 (Talk) Development of novel Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) to prevent biomaterial-associated infection. (Published: Ned. Tijdschr. Med. Microbiol., 23 (Suppl) 2015, S18)

P.H. Nibbering Gordon Research Conference on Antimicrobial peptides, Italy, April 2015 (Talk) Development and formulation of novel synthetic antimicrobial peptides for treatment of skin infections and colonization.

S.A.J. Zaat EFORT conference, Czech Republic, May 2015 (Invited Talk) Synthetic antimicrobial and antibiofilm peptides to prevent biomaterial-associated infection.

W.J. Metsemakers, N. Emanuel, O. Cohen, M. Reichert, T. Schmid, R.G. Richards, D. Segal and T.F. Moriarty EFORT conference, Czech Republic, May 2015 (Poster) Prevention of implant-related osteomyelitis using a doxycycline coating in a humeral non-fracture rabbit model.

S.A.J. Zaat Improving outcomes in Complex Abdominal Wall Reconstruction (Acility meeting), Amsterdam, The Netherlands, May 2015 (Invited Talk) Biomaterial-associated infection.

S.A.J. Zaat, M. Riool, A. de Breij P.H.S. Kwakman, L. de Boer, P.H. Nibbering , R.A. Cordfunke, J.W. Drijfhout, P.S. Hiemstra , N. Malanovic , K. Lohner, O. Cohen, N. Emanuel and T.F. Moriarty. eCM, Switzerland, June 2015 (Invited Talk) Synthetic antimicrobial antibiofilm peptides from controlled release coatings to prevent implant-associated infection and derangement of immune responses. (Published: eCM, 30 (Suppl 2) 2015, S26)

M. Riool, P.H.S. Kwakman, L. de Boer, A. de Breij, P.H. Nibbering, L.T. Nguyen, H.J. Vogel, J.W. Drijfhout and S.A.J. Zaat eCM, Switzerland, June 2015 (Poster) Development of novel Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) using the trombocidin-1 derived peptide L3 as a scaffold. (Published: eCM, 30 (Suppl 2) 2015, 67)

N. Emanuel, W.J. Metsemakers, O. Cohen, R.O. Estrada, M. Reichert, A. de Breij, I. Potapova, T. Schmid, D. Segal, R.G. Richards, S.A.J. Zaat and T.F. Moriarty eCM, Switzerland, June 2015 (Talk) Efficacy of a lipid-and-polymer-based drug delivery coating containing doxycycline for the prevention of implant-related osteomyelitis. (Published: eCM, 30 (Suppl 2) 2015, 34)

N. Malanovic, R. Leber, M. Kriechbaum, J.W. Drijfhout and K. Lohner. American Peptide Symposium, Orlando 2015, USA , June 2015 (Poster) Interaction of OP-145, a derivative of human cathelicidin LL-37, with Gram+ bacterial plasma membrane and cell wall components: impact of secondary structure and aggregation.

W.J. Metsemakers et al. 34th European Bone and Joint Infection Society, Lisbon, Portugal, September 2015 (Talk) Prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus using a doxycycline-loaded polymer-lipid encapsulation matrix coating.

A. de Breij, M. Riool, P.H.S. Kwakman, A. van Assche, J. de Keijzer, T. van der Heijden, A. Adriaans, E. Ravensbergen, R.A. Cordfunke, J.W. Drijfhout, S.A.J. Zaat and P.H. Nibbering Phenotype Microarray conference, Italy, September 2015 (Talk) A proteomic and phenomic approach to study the effect of the antimicrobial peptide OP-145 on Staphylococcus aureus.

K. Lohner. IMAP 2015, London, UK, September 2015 (Invited Talk) Impact of cell wall components on the efficacy of antimicrobial peptides toward Gram-positive and Gram-negative bacteria.

A. de Breij, M. Riool, P.H.S. Kwakman, L. de Boer, R.A. Cordfunke, J.W. Drijfhout, O. Cohen, N. Emanuel, S.A.J. Zaat, P.H. Nibbering and T.F. Moriarty COATIM final meeting, Belgium, December 2015 (Talk) Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145.

S.A.J. Zaat COATIM final meeting, Belgium, December 2015 (Invited Talk) Overview of FP7 project BALI (Biofilm Alliance).

M. Riool, P.H.S. Kwakman, L. de Boer, A. de Breij, P.H. Nibbering, L.T. Nguyen, H.J. Vogel, J.W. Drijfhout and S.A.J. Zaat COATIM final meeting, Belgium, December 2015 (Poster) Development of novel Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) using the trombocidin-1 derived peptide L3 as a scaffold.

M. Riool, A. de Breij, P.H.S. Kwakman, L. de Boer, R.A. Cordfunke, J.W. Drijfhout, O. Cohen, N. Emanuel, S.A.J. Zaat, P.H. Nibbering and T.F. Moriarty Dutch Society for Biomaterials and Tissue Engineering (NBTE), Lunteren, The Netherlands, December 2015 (Talk) Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145.

N. Malanovic, R.A. Cordfunke, J.W. Drijfhout, A. de Breij, P.H. Nibbering and K. Lohner. 5th Austrian Peptide Symposium, Vienna 2015, Austria, December 2015 (Talk) Peptide aggregation as one of the key factors for affinity and selectivity toward phospholipid membranes.

N. Malanovic, R.A. Cordfunke, J.W. Drijfhout, A. de Breij, P.H. Nibbering, and K. Lohner. Anti-infective strategies for medical devices, Joint Meeting of BALI, BackAttack and COATIM, Leuven 2015, Belgium, December 2015 (Poster) Mode of Action of Synthetic Antimicrobial Peptide OP-145 and its derivatives on Gram-positive Bacterial and Mammalian Membrane Model Systems is triggered by their structural properties.

S.A.J. Zaat iPROMEDAI focus group meeting on cardiovascular device related infections, Berlin, Germany, December 2015 (Invited Talk) “Cardiac output”, from infective endocarditis to infection-free biomaterials.

S.A.J. Zaat iPROMEDAI science and technology meeting, Bratislava, Slovakia, February 2016 (Invited Talk) In vivo biomaterial-associated infection models.

S.A.J. Zaat Abdominal Wall Reconstruction, London, United Kingdom, February 2016 (Invited Talk) Biomaterial infections: the science.

M. Riool, A. de Breij, P.H.S. Kwakman, L. de Boer, R.A. Cordfunke, J.W. Drijfhout, O. Cohen, N. Emanuel, P.H. Nibbering, T. Fintan Moriarty and S.A.J. Zaat Dutch society of (medical) microbiology (KNVM/NVMM), Arnhem, The Netherlands, March 2016 (Talk) Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing LL-37-derived antimicrobial peptides. (Published: Ned. Tijdschr. Med. Microbiol., 24 (Suppl) 2016, S41)

A. de Breij, M. Riool, E.M. Haisma, L. de Boer, R.A. Cordfunke, J.E. Stalenhoef, D. Schriel, A.E. Adriaans, A. El Ghalbzouri, B.K. Boekema, J.W. Drijfhout, S.A.J. Zaat and P.H. Nibbering. ALTANT conference, Utrecht, May 2016 (Poster) New synthetic antimicrobial and antibiofilm peptides are effective against drug-resistant wound pathogens.

M. Riool, A. de Breij, P.H.S. Kwakman, L. de Boer, R.A. Cordfunke, J.W. Drijfhout, O. Cohen, N. Emanuel, P.H. Nibbering, T.F. Moriarty and S.A.J. Zaat. ALTANT conference, Utrecht, May 2016 (Talk) Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing LL-37-derived antimicrobial peptides.