The BALI consortium performs multidisciplinary research to design Synthetic Antimicrobial Antibiofilm Peptides (SAAP) and a release system which can be applied to the surface of biomaterials as a coating. We aim to develop novel SAAPs with optimized in vitro antimicrobial, anti-inflammatory and biofilm-dispersing activity (WP2) and to investigate their mode of action (WP3). An innovative delivery formulation (PolyPid platform) will be used to allow prolonged and pre-determined release rates of the most promising SAAPs (WP4). This platform ensures local delivery of effective concentrations of the peptide over a sufficient duration and can be developed into coatings for different types of implants. To obtain in vivo proof of concept, the efficacy to prevent and treat biomaterial-associated infections of PolyPid/SAAP-coated polymer and titanium implants will be tested in various clinically relevant in vivo model systems (WP5 and WP6). Results will be actively disseminated to specialized and general audiences (WP8).